In 1959, psychiatrist Dr. Alan Stone (Richard Gere) arrives at a mental hospital in Ypsilanti, Michigan armed with the radical belief that schizophrenic patients should be treated not with confinement and electroshock therapy but with empathy and understanding. As his first study, he takes on the particularly challenging case of three men—Joseph (Peter Dinklage), Leon (Walton Goggins), and Clyde (Bradley Whitford)—each of whom believes they are Jesus Christ.
